ATMI Life Sciences

single-use bioprocess systems and consumables

ATMI LifeSciences is an acknowledged technology leader in the field of single-use bioprocess systems and consumables for the pharmaceutical and biopharmaceutical industries.

ATMI LifeSciences has manufacturing facilities in Hoegaarden, Belgium; Bloomington, Minnesota and Lexington, Kentucky, USA and Toyohashi, Japan, with capabilities to produce hardware and single-use vessels for disposable mixing, bioreactor and storage systems as well as fluoropolymer-based products and custom engineered, flexible packaging solutions. ATMI LifeSciences also maintains process application laboratories, multidisciplined product development teams, quality and global customer service and support networks.

Its innovative, market-leading portfolio of single-use disposable storage systems, mixers and bioreactors is driving bioprocess efficiency and delivering value for biopharmaceutical companies around the world.

Single Use Bioreactors - Making them Big

February 18, 2012

Large volume production is a must for the cell therapy sector according to ATMI, which claims the latest addition to its single-use bioreactor range can help manufacturers overcome the GMP hurdles that hinder commercial scale-up.

ATMI launched a new technology for enabling large-scale, cell-based manufacturing as the company unveiled its Integrity™ Xpansion™ Bioreactor Systems at the Cell Therapy Manufacturing Conference in Brussels, Belgium. The new line of bioreactors are part of the ATMI LifeSciences Integrity family of single-use technologies and have been especially developed for fragile adherent cell culture applications (such as stem cells) on a large scale. The Integrity Xpansion product line represents the first commercially-available bioreactors that support safe and cost-efficient large-scale (large volume) production of traditional two-dimensional (2-D) cell cultures with the advantage of cell culture parameter controls.

- Compact and efficient, 2D multiplate design

- Scalable, single use closed system

- Cell Culture parameters control

- Cell Morphology and density monitoring

"It is essential that cell therapies can be made efficiently and effectively on a large scale for them to reach the market. Yet, it can be a challenge to achieve GMP standards during large-scale production because of a lack of efficient cell culture technologies — many of which can lead to bottlenecks and prohibitive costs," says Jose Castillo, the global director of cell culture technologies for ATMI LifeSciences. "The Xpansion bioreactors represent a solution for process industrialization for cell therapies. Both patient safety and GMP compliance have been factored into the system's design, as has operational simplicity. Space and cost requirements have been drastically reduced, enabling the user to operate in a manner that existing large-scale technologies cannot match."

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ATMI Life Sciences - Cell Therapy Process and Cost Model Simulations.pdf

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Standardizing Films for Single-Use Bioprocessing Vessels

October 6, 2011

More and more biopharmaceutical organizations start to realise the importance of a reliable counterpart for their disposable processing needs.

Stainless steel and glass have long dominated the biomanufacturing market as accepted materials for bioprocess mixing, bioreactor, feed, collection, formulation, and shipping vessels. Although single-use storage bags quickly found their way into process development and GMP manufacturing, the concept of singleuse mixing and bioreactor vessels was not seriously considered as an option until recently. Today, most biopharmaceutical organizations accept that single-use mixing and bioreactor platforms also offer operational, technical, and economic advantages.

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ATMI Standardizing Films for Single-Use Bioprocessing Vessels white paper.pdf