During the initial stages of scale-up, researchers often have limited data available with which they must decide on what to do next. High throughput, informative and predictive tools are necessary to cope with the number of cultures that must be done early on.
The Micro-Flask system by Applikon, is a simple and powerful set of tools for improving the quality of experiments performed in micro-titer plates. Using a unique “sandwich cover” plate closure, it is possible to eliminate well-to-well variability in flasks, dramatically improve gas transfer in cultures, and achieve outstanding results from high-throughput experimentation.
The Micro bioreactor ensures that every microtiter plate is exposed to identical culture conditions. In addition to preventing cross-contamination during vigorous shaking, the sandwich covers also provide uniform diffusion paths for each well, virtually eliminating well-to-well variability.