Cream Manufacturing Equipment

Find innovative production technology for making cream and connect directly with world-leading specialists.

Cream
Tell us about your production challenge
The topical route is a convenient route for the self-administration of drugs. But turning a pharmaceutical formulation into an easy-to-use cream involves specialized cream manufacturing equipment. Topical dosage forms are essentially an emulsion of oil and water.  But the ratios can be changed to process it into lotions, ointments, and gels.

Which cream technology do you need?

Emulsifier for cosmetic creams

Emulsifier for cosmetic creams

The process of making cream and lotion involves mixing of water phase and oil phase to create …

Cosmetic cream filler

Cosmetic cream filler

From thin liquid baby oils and perfumes to thicker lotions and creams for hair and skincare, cosmetic pr…

High shear lab mixer for creams

High shear lab mixer for creams

Lab-scale mixers are vital in the design or small-batch production of a range of pharmaceutic…

Filling machine for creams

Filling machine for creams

Liquid cosmetics have particular requirements when it comes to filling and capping containers. Mor…

Homogenizer for creams

Homogenizer for creams

Homogenization (or pharmaceutical micronization) is the process of reducing particle sizes, and is a vi…

Complete cutting, mixing, emulsifying and heating system

Complete cutting, mixing, emulsifying and heating system

From laboratory scale to large volume food or cosmetic production…

Pilot plant homogeniser

Pilot plant homogeniser

From food to pharma, homogenization is an essential step in the production process that provides unifo…

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Pilot ultrasonic extractor

Pilot ultrasonic extractor

In the herbal medicine industry, an ultrasonic extractor is a valid alternative to conventional ex…

Batch vacuum mixer for emulsion-based products

Batch vacuum mixer for emulsion-based products

The production of creams or ointments can be either be a water in oil (w/o) …

Pharmaceutical formulation and mixing tanks

Pharmaceutical formulation and mixing tanks

Preparation lines for formulating pharmaceuticals include fixed and mobile tank…

Sachet Machine

Sachet Machine

If you want to pack into eye-catching 4-side sealed sachets between 40x50 mm and 250x200 mm in size, investing i…

Agitator bead mill for API

Agitator bead mill for API

To achieve precisely defined API properties and safe and reproducible production, rigorous impleme…

Flexible R&D wet agitator mill for cosmetics

Flexible R&D wet agitator mill for cosmetics

Using nanoparticles in cosmetics requires precise control over material breakd…

Up to four head automatic filling machine

Up to four head automatic filling machine

When your consumer demand is increasing you will need new and more effective pack…

R&D bottle washer

R&D bottle washer

When you pack your products in bottles, vials, syringes, and test tubes you need to wash them before filling…

Manual metal tube sealing equipment

Manual metal tube sealing equipment

For small-batch productions where you utilize metal tubes as containers for your product…

Self-adhesive linear labeling machine for bottles

Self-adhesive linear labeling machine for bottles

It is vital to have precise and long-lasting labels on bottles to avoid …

Bulk chamber washer

Bulk chamber washer

The production of cosmetics, nutraceuticals or unregulated pharmaceuticals often requires the cleaning and…

Entry-level chamber washer

Entry-level chamber washer

When cleaning smaller products contacting filling or compressing components used in the production…

Loading basket for GMP washer

Loading basket for GMP washer

To ensure perfect cleaning of contact parts they must be placed in the GMP washer in such a way…

High-capacity horizontal cartoner for pharma and cosmetics appliances

High-capacity horizontal cartoner for pharma and cosmetics appliances

Cartoners take carton blanks which are formed and …

Automatic cartoner for applications in pharma and cosmetics

Automatic cartoner for applications in pharma and cosmetics

For high capacity production of cosmetics and pharmaceuticals…

Pharmaceutical and cosmetic industry products cartoner

Pharmaceutical and cosmetic industry products cartoner

A large number of cosmetic and pharmaceutical products are packed i…

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Horizontal cartoner for pharma and cosmetics

Horizontal cartoner for pharma and cosmetics

Most pharmaceutical and cosmetics products are packed in cardboard cartons for…

High capacity cartoner for pharmaceutical applications

High capacity cartoner for pharmaceutical applications

Many pharmaceutical products are packed in protective and decorativ…

Vertical cartoner for pharmaceutical applications

Vertical cartoner for pharmaceutical applications

Many pharmaceutical and cosmetic products are sold in protective and dec…

Tube unloader and feeder

Tube unloader and feeder

The pharmaceutical and cosmetic industries utilise high speed tube fillers on large-scale production …

Tube feeding unit for high volume and high speed tube filler

Tube feeding unit for high volume and high speed tube filler

High performance tube-filling machines are used for large sc…

Tube feeder for a small scale production tube filler

Tube feeder for a small scale production tube filler

Low speed tube-filling machines are used for small scale production l…

Loading cassette for a tube filler

Loading cassette for a tube filler

High performance tube-filling machines are used in the pharmaceutical and cosmetic indust…

High speed automatic tube filler

High speed automatic tube filler

For high-volume lines filling pharmaceutical, cosmetic or food products into tube containers…

Medium and high speed range automatic tube filler

Medium and high speed range automatic tube filler

When scaling up production of pharmaceutical, food or cosmetic products …

Medium speed tube filler and sealer

Medium speed tube filler and sealer

For scale-up filling of tube packaging for pharmaceuticals, cosmetics and food products,…

Low speed tube filler

Low speed tube filler

Increasing numbers of products in the pharmaceutical, cosmetic and food industries are delivered in flex…

A two-component filling application tube filler

A two-component filling application tube filler

A wide variety of pharmaceutical, cosmetic and food products require tube-s…

Stories about cream

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Raise the API content to 99%


Pharmaceutical creams are mostly used to treat skin issues such as rashes, stings, or fungal infections. Unlike cosmetic creams, medicated creams penetrate the epidermis and target cells in the lower layers of the skin.


Pharmaceutical creams must contain 99% pure active ingredients. However, APIs are applied in lower concentrations than in other formulations like tablets.


Mix the water and oil phases to produce a stable emulsion

The preparation of oil and water phases involves different cream manufacturing equipment. Oils are extracted and purified from biological materials using extraction technology. Water is filtered from contaminants and distilled.

The two come together in specialized mixing systems that suspend the liquids into an emulsion. A finer droplet renders a more stable emulsion and a smoother cream consistency.

Disperse the drugs and additives in the liquids before emulsification

The oil phase can be either a mineral oil or a silicone, enriched with emollients and lubricants. If the additives are in wax form, heating equipment is used to melt them into the oil base.

Excipients such as binders, thickeners, and stabilizers help the two phases to emulsify. But these agents are dispersed into the water phase. Active ingredients are dispersed into both phases depending on their reactive properties.

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Use high-shear mixing equipment to prevent lumps


Not all mixing technologies are suitable for manufacturing pharmaceutical creams. The mechanism needs to incorporate the drugs (typically in powder form) into the emulsion droplets. Failing to combine the materials homogeneously causes agglomerate in the formulation down the line.


High-shear mixers disperse the API and excipients uniformly in the oil and water phases. Similarly, the high rate of agitation lowers the interfacial tension between the phases, producing a more stable emulsion.


Add viscosity modifiers to retain a consistent texture in creams

Excipients are used to facilitate drug delivery. But, at the same time, molecules can coalesce into a microstructure forming large crystals.

Lubricants keep the fluidity of the formulation. But changing temperatures alter their behavior, and creams may feel greasy in warmer environments. Viscosity modifiers reduce the change of stickiness in lubricants to keep a consistent structure.

How to pack your creams and ointments


When filling topical formulations it is essential to get the amount of product in various consistencies per container just right and to be able to accommodate various container shapes and sizes. There are many factors that influence the decision for choosing a container to fill in topical dosage forms. Some of these factors are materials and visual appearance while others are specific to the usage of the product filled. The most common containers for filling creams are tubes and glass or plastic jars.


Tubes have narrow openings that protect the creams against contamination and preserve the product’s shelf life. Tubes are mostly made from low or high-density polyethylene and aluminum. They have various top shapes that can be applied. For example, triangular toppers allow to push out as much product as needed with precision. Push tops are also common for creams that need controlled amounts produced with each pump. Tubes can be of different diameters ranging from 16mm to 50mm and the capacity ranging from 5ml to 240ml. A filling machine, therefore, becomes a critical piece of equipment for any cream manufacturing plant.


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